The purpose of this work is to study and compare the impacts of climate change in three regions of Greece, in particular in Sterea Ellada, Thessaly and the Peloponnese. This crisis refers to the impacts of Climate Change, both current and expected, and concerns the social, economic and natural environment, the perceptions of people and the competent authorities, as well as the planning policies which either incorporate or not appropriate mitigation and adaptation measures. In the present work the authors test the fundamental hypothesis, that outdated regional plans and climatic blind regional policies are inadequate in coping with the challenges arising from new climatic environments which characterize new or more pronounced climatic and meteorological risks and vulnerabilities.